RESEARCH ARTICLES:
2021-2024
Macrophage activation markers are associated with infection and mortality in patients with acute liver failure. Cavazza A, Triantafyllou E, Savoldelli R, Mujib S, Jerome E, Trovato FM, Artru F, Sheth R, Huang XH, Ma Y, Dazzi F, Pirani T, Antoniades CG, Lee WM, McPhail MJ, Karvellas CJ; US Acute Liver Failure Study Group. Liver Int. 2024 Apr 8. doi: 10.1111/liv.15928. PMID: 38588014
Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis. Gudd CLC, Mitchell E, Atkinson SR, Mawhin MA, Turajlic S, Larkin J, Thursz MR, Goldin RD, Powell N, Antoniades CG, Woollard KJ, Possamai LA, Triantafyllou E. J Immunother Cancer. 2024 Apr 4;12(4):e008078. doi: 10.1136/jitc-2023-008078. PMID: 38580334
Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus. Forlano R, Martinez-Gili L, Takis P, Miguens-Blanco J, Liu T, Triantafyllou E, Skinner C, Loomba R, Thursz M, Marchesi JR, Mullish BH, Manousou P. Gut Microbes. 2024 Jan-Dec;16(1):2304157. doi: 10.1080/19490976.2024.2304157. Epub 2024 Jan 18. PMID: 38235661
AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells. Pop OT, Geng A, Flint E, Singanayagam A, Ercan C, Possamai L, Patel VC, Kuenzler P, Meier MA, Soysal S, Hruz P, Kollmar O, Tatham KC, Ward JK, Müllhaupt B, Weber A, Wendon J, Niess JH, Heim M, Semela D, Weston C, Antoniades CG, Terracciano LM, Triantafyllou E, Brenig RG, Bernsmeier C. Cell Mol Gastroenterol Hepatol. 2023;16(1):17-37. doi: 10.1016/j.jcmgh.2023.03.007. Epub 2023 Mar 31. PMID: 37004869
Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure. Trovato FM, Zia R, Artru F, Mujib S, Jerome E, Cavazza A, Coen M, Wilson I, Holmes E, Morgan P, Singanayagam A, Bernsmeier C, Napoli S, Bernal W, Wendon J, Miquel R, Menon K, Patel VC, Smith J, Atkinson SR, Triantafyllou E, McPhail MJW. J Hepatol. 2023 Mar;78(3):558-573. doi: 10.1016/j.jhep.2022.10.031. Epub 2022 Nov 9. PMID: 36370949
Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis. Khamri W, Gudd C, Liu T, Nathwani R, Krasniqi M, Azam S, Barbera T, Trovato FM, Possamai L, Triantafyllou E, Seoane RC, Lebosse F, Singanayagam A, Kumar N, Bernsmeier C, Mukherjee S, McPhail M, Weston CJ, Antoniades CG, Thursz MR. Gut. 2022 Jun;71(6):1192-1202. doi: 10.1136/gutjnl-2021-324071. Epub 2021 Aug 3. PMID: 34344786
Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute-on-Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid-Dependent Monocyte Activation. Trovato FM, Zia R, Napoli S, Wolfer K, Huang X, Morgan PE, Husbyn H, Elgosbi M, Lucangeli M, Miquel R, Wilson I, Heaton ND, Heneghan MA, Auzinger G, Antoniades CG, Wendon JA, Patel VC, Coen M, Triantafyllou E, McPhail MJ. Hepatology. 2021 Aug;74(2):907-925. doi: 10.1002/hep.31738. Epub 2021 Jun 15. PMID: 33908067
Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis. Gudd CLC, Au L, Triantafyllou E, Shum B, Liu T, Nathwani R, Kumar N, Mukherjee S, Dhar A, Woollard KJ, Yone Y, Pinato DJ, Thursz MR, Goldin RD, Gore ME, Larkin J, Khamri W, Antoniades CG, Turajlic S, Possamai LA. J Hepatol. 2021 Jul;75(1):177-189. doi: 10.1016/j.jhep.2021.02.008. Epub 2021 Feb 22. PMID: 33631227
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury. Triantafyllou E, Gudd CL, Mawhin MA, Husbyn HC, Trovato FM, Siggins MK, O'Connor T, Kudo H, Mukherjee SK, Wendon JA, Bernsmeier C, Goldin RD, Botto M, Khamri W, McPhail MJ, Possamai LA, Woollard KJ, Antoniades CG, Thursz MR. J Clin Invest. 2021 Feb 15;131(4):e140196. doi: 10.1172/JCI140196. PMID: 33320839
2014-2020
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C. Life Sci Alliance. 2019 Dec 10;3(1):e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan. PMID: 31822557
CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction. Lebossé F, Gudd C, Tunc E, Singanayagam A, Nathwani R, Triantafyllou E, Pop O, Kumar N, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Dhar A, Thursz M, Antoniades CG, Khamri W. EBioMedicine. 2019 Nov;49:258-268. doi: 10.1016/j.ebiom.2019.10.011. Epub 2019 Oct 31. PMID: 31678004
CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG. Gut. 2018 Jun;67(6):1155-1167. doi: 10.1136/gutjnl-2017-314184. Epub 2017 Jun 7. PMID: 28592438
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG. Gut. 2018 Feb;67(2):333-347. doi: 10.1136/gutjnl-2016-313615. Epub 2017 Apr 27. PMID: 28450389
Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. Gastroenterology. 2017 Jul;153(1):263-276.e8. doi: 10.1053/j.gastro.2017.03.023. Epub 2017 Mar 28. PMID: 28363639
Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis. McPhail MJW, Shawcross DL, Lewis MR, Coltart I, Want EJ, Antoniades CG, Veselkov K, Triantafyllou E, Patel V, Pop O, Gomez-Romero M, Kyriakides M, Zia R, Abeles RD, Crossey MME, Jassem W, O'Grady J, Heaton N, Auzinger G, Bernal W, Quaglia A, Coen M, Nicholson JK, Wendon JA, Holmes E, Taylor-Robinson SD. J Hepatol. 2016 May;64(5):1058-1067. doi: 10.1016/j.jhep.2016.01.003. Epub 2016 Jan 18. PMID: 26795831
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triantafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J. J Hepatol. 2016 Jan;64(1):69-78. doi: 10.1016/j.jhep.2015.08.018. Epub 2015 Aug 29. PMID: 26325537
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG. Gastroenterology. 2015 Mar;148(3):603-615.e14. doi: 10.1053/j.gastro.2014.11.045. Epub 2014 Dec 3. PMID: 25479139
Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure. Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O'Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M. Hepatology. 2014 Apr;59(4):1564-76. doi: 10.1002/hep.26933. Epub 2014 Feb 28. PMID: 24282114
REVIEW ARTICLES:
Immune Checkpoint Inhibitor-Induced Liver Injury. Gudd CLC, Sheth R, Thursz MR, Triantafyllou E, Possamai LA. Semin Liver Dis. 2023 Nov;43(4):402-417. doi: 10.1055/s-0043-1776761. Epub 2023 Dec 15. PMID: 38101418
Potential therapies for acute-on-chronic liver failure. Morrison MA, Artru F, Trovato FM, Triantafyllou E, McPhail MJ. Liver Int. 2023 Feb 17. doi: 10.1111/liv.15545. Online ahead of print. PMID: 36800487
Lipids in Liver Failure Syndromes: A Focus on Eicosanoids, Specialized Pro-Resolving Lipid Mediators and Lysophospholipids. Artru F, McPhail MJW, Triantafyllou E, Trovato FM. Front Immunol. 2022 Mar 31;13:867261. doi: 10.3389/fimmu.2022.867261. eCollection 2022. PMID: 35432367
Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting. Singanayagam A, Triantafyllou E. Front Immunol. 2021 Apr 2;12:661182. doi: 10.3389/fimmu.2021.661182. eCollection 2021. PMID: 33868313
The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure. Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG, Possamai LA. Front Immunol. 2018 Dec 14;9:2948. doi: 10.3389/fimmu.2018.02948. eCollection 2018. PMID: 30619308